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apalutamide will decrease the extent or influence of diazepam by impacting hepatic enzyme CYP2C19 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a strong CYP2C19 inducer, with medicine which are CYP2C19 substrates may lead to lessen publicity to those medicines.diazepam will enhance the stage or outcome of isavuconazoni